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az compound 39  (AstraZeneca ltd)

 
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    AstraZeneca ltd az compound 39
    Az Compound 39, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/az+compound+39/az+compounds/pmc11265541-36-0-4
    Average 90 stars, based on 1 article reviews
    az compound 39 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Chromatin Immunoprecipitation:

    Article Title: Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies V5 tag (D3H8Q) Cell Signaling Technology Cat# 13202; Lot 4 RRID: AB_2687461 KMT2D K1330me1/me2 Eurogentec Custom KMT2D pS1331 Eurogentec Custom Vinculin Cell Signaling Technology Cat# 4650 RRID: AB_10559207 KMT2D Fortis LifeSciences Cat# A300-BL1185, RB X-ALR phospho-AKT (Ser473) (D9E) Cell Signaling Technology Cat# 4060 RRID: AB_2315049 phospho-RXRXX(S/T) (23C8D2) Cell Signaling Technology Cat# 10001 RRID: AB_10950819 HA tag (C29F4) Cell Signaling Technology Cat# 3724 RRID: AB_1549585 SMYD2 (D14H7) Cell Signaling Technology Cat #9734 RRID: AB_10889559 DYKDDDDK Tag (D6W5B) Rabbit mAb Cell Signaling Technology Cat #14793; Lot 7 RRID: AB_2572291 ECLTM Anti-Rabbit IgG Horseradish Peroxidase linked whole antibody (from donkey) GE Healthcare Cat# NA934V; Lot 17010251 RRID: AB_772206 KMT2D ChIP antibody Sigma Aldrich Cat# HPA035877 RRID: AB_10670673 V5 antibody Abcam Cat#ab9116 RRID:AB_307024 H3 Antibody Abcam Cat #ab1791 RRID: AB_302613 Bacterial and virus strains NEB 5-alpha Competent E. coli (High Efficiency) NEB Cat# C2987H Chemicals, peptides, and recombinant proteins 3H-SAM Perkin Elmer NET155V250UC Ultima Gold Scintillation Cocktail Revvity Cat# 6013321 a-Cyano-4-hydroxycinnamic acid Sigma Aldrich Cat#C8982 KMT2D peptides (unmodified, K1330me1, K1330me2, pS1331) Sequence: AHGGRGRGRARL KSTASSIETLVVAD GenScript Custom V5-agarose beads Millipore Sigma Cat# A7345 EZviewTM RED Anti-HA agarose beads Millipore Sigma Cat# E6779 H3 peptide (aa1-21) Genscript Custom MK2206 Selleckchem Catalog No.S1078 Alpelisib Medchem Express Cat# HY-15244 Capivasertib AstraZeneca N/A Fulvestrant Selleckchem Cat# S1191 LLY-507 Sigma Aldrich Cat# SML1279 AZ506 Medchem Express Cat# HY-134828 EPZ033294 Viva Biotech N/A AZ Compound 39 Astra Zeneca N/A (Continued on next page) 16 Cell Reports 43, 114174, May 28, 2024 .. REAGENT or RESOURCE SOURCE IDENTIFIER Doxycycline hydrochloride Millipore Sigma Cat #D3447 Dimethyl Sulfoxide Corning Cat# 25-950-CQC; Lot 01019003 Crystal Violet Sigma Aldrich Cat #V5265 PrestoBlue ThermoFisher Scientific Cat #A13262 Y-27632 Tocris Cat# 1254 TrypLE ThermoFisher Scientific Cat# 12605036 Protein G Dynabeads ThermoFisher Scientific Cat #10004D AMPure beads XP Beckman Coulter A63880 SYBRTM Select Master Mix for CFX Applied Biosystems Cat# 4472942; Lot 00815825 Matrigel Corning Cat# 354262 Lipofectamine 3000 ThermoFisher Scientific Cat# L3000015 Recombinant AKT1 SignalChem Cat#A16-10G Recombinant AKT2 SignalChem Cat #A17-10H Recombinant AKT3 SignalChem Cat #A18-10G Recombinant SGK1 SignalChem Cat #S06-10G Critical commercial assays QuikChange Lightning Site-Directed Mutagenesis Kit Agilent Cat#210518 Q5 mutagenesis kit NEB Cat #E0552S Roche MTT kit Millipore Sigma Cat# 11465007001 Cell-Titer Glo 3D Promega Cat# G9681 Qiagen RNeasy Mini Kit (250) Qiagen Cat# 74106; Lot 163029673 iScriptTM cDNA Synthesis Kit Bio-Rad Cat# 1708891 CUTANA CUT & RUN Kit EpiCypher Cat# 14-1048 CUTANA CUT & RUN Library Prep Kit EpiCypher Cat# 14-1001 Deposited data ChIP-seq/RNA-seq/Cut&Run fastq files This paper GSE255295, GSE253957, GSE253958 Experimental models: Cell lines h-MCF7 ATCC ATCC HTB-22TM h-T47D ATCC ATCC HTB-133TM h-293T ATCC ATCC CRL-3216TM HCI-011 Welm Laboratory N/A HCI-017 Welm Laboratory N/A HCI-018 Welm Laboratory N/A Homozygous KMT2D K1330A (AAG>gcG) clones Synthego Custom Experimental models: Organisms/strains Female NSG mice Antitumor assessment core (MSKCC) N/A Oligonucleotides h-GREB1 F: GACAGGACTGTGGACTGGTG R: ATTTGTTTCCAGCCCTCCTT IDT N/A h-TFF1 F: TTGTGGTTTTCCTGGTGTCA R: CCGAGCTCTGGGACTAATCA IDT N/A h-WISP2 F: CAGGGGTCGCAGTCCACAAAA R: AGGCAGTGAGTTAGAGGAAAGG IDT N/A (Continued on next page) Cell Reports 43, 114174, May 28, 2024 17 Article ll OPEN ACCESS

    Virus:

    Article Title: Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies V5 tag (D3H8Q) Cell Signaling Technology Cat# 13202; Lot 4 RRID: AB_2687461 KMT2D K1330me1/me2 Eurogentec Custom KMT2D pS1331 Eurogentec Custom Vinculin Cell Signaling Technology Cat# 4650 RRID: AB_10559207 KMT2D Fortis LifeSciences Cat# A300-BL1185, RB X-ALR phospho-AKT (Ser473) (D9E) Cell Signaling Technology Cat# 4060 RRID: AB_2315049 phospho-RXRXX(S/T) (23C8D2) Cell Signaling Technology Cat# 10001 RRID: AB_10950819 HA tag (C29F4) Cell Signaling Technology Cat# 3724 RRID: AB_1549585 SMYD2 (D14H7) Cell Signaling Technology Cat #9734 RRID: AB_10889559 DYKDDDDK Tag (D6W5B) Rabbit mAb Cell Signaling Technology Cat #14793; Lot 7 RRID: AB_2572291 ECLTM Anti-Rabbit IgG Horseradish Peroxidase linked whole antibody (from donkey) GE Healthcare Cat# NA934V; Lot 17010251 RRID: AB_772206 KMT2D ChIP antibody Sigma Aldrich Cat# HPA035877 RRID: AB_10670673 V5 antibody Abcam Cat#ab9116 RRID:AB_307024 H3 Antibody Abcam Cat #ab1791 RRID: AB_302613 Bacterial and virus strains NEB 5-alpha Competent E. coli (High Efficiency) NEB Cat# C2987H Chemicals, peptides, and recombinant proteins 3H-SAM Perkin Elmer NET155V250UC Ultima Gold Scintillation Cocktail Revvity Cat# 6013321 a-Cyano-4-hydroxycinnamic acid Sigma Aldrich Cat#C8982 KMT2D peptides (unmodified, K1330me1, K1330me2, pS1331) Sequence: AHGGRGRGRARL KSTASSIETLVVAD GenScript Custom V5-agarose beads Millipore Sigma Cat# A7345 EZviewTM RED Anti-HA agarose beads Millipore Sigma Cat# E6779 H3 peptide (aa1-21) Genscript Custom MK2206 Selleckchem Catalog No.S1078 Alpelisib Medchem Express Cat# HY-15244 Capivasertib AstraZeneca N/A Fulvestrant Selleckchem Cat# S1191 LLY-507 Sigma Aldrich Cat# SML1279 AZ506 Medchem Express Cat# HY-134828 EPZ033294 Viva Biotech N/A AZ Compound 39 Astra Zeneca N/A (Continued on next page) 16 Cell Reports 43, 114174, May 28, 2024 .. REAGENT or RESOURCE SOURCE IDENTIFIER Doxycycline hydrochloride Millipore Sigma Cat #D3447 Dimethyl Sulfoxide Corning Cat# 25-950-CQC; Lot 01019003 Crystal Violet Sigma Aldrich Cat #V5265 PrestoBlue ThermoFisher Scientific Cat #A13262 Y-27632 Tocris Cat# 1254 TrypLE ThermoFisher Scientific Cat# 12605036 Protein G Dynabeads ThermoFisher Scientific Cat #10004D AMPure beads XP Beckman Coulter A63880 SYBRTM Select Master Mix for CFX Applied Biosystems Cat# 4472942; Lot 00815825 Matrigel Corning Cat# 354262 Lipofectamine 3000 ThermoFisher Scientific Cat# L3000015 Recombinant AKT1 SignalChem Cat#A16-10G Recombinant AKT2 SignalChem Cat #A17-10H Recombinant AKT3 SignalChem Cat #A18-10G Recombinant SGK1 SignalChem Cat #S06-10G Critical commercial assays QuikChange Lightning Site-Directed Mutagenesis Kit Agilent Cat#210518 Q5 mutagenesis kit NEB Cat #E0552S Roche MTT kit Millipore Sigma Cat# 11465007001 Cell-Titer Glo 3D Promega Cat# G9681 Qiagen RNeasy Mini Kit (250) Qiagen Cat# 74106; Lot 163029673 iScriptTM cDNA Synthesis Kit Bio-Rad Cat# 1708891 CUTANA CUT & RUN Kit EpiCypher Cat# 14-1048 CUTANA CUT & RUN Library Prep Kit EpiCypher Cat# 14-1001 Deposited data ChIP-seq/RNA-seq/Cut&Run fastq files This paper GSE255295, GSE253957, GSE253958 Experimental models: Cell lines h-MCF7 ATCC ATCC HTB-22TM h-T47D ATCC ATCC HTB-133TM h-293T ATCC ATCC CRL-3216TM HCI-011 Welm Laboratory N/A HCI-017 Welm Laboratory N/A HCI-018 Welm Laboratory N/A Homozygous KMT2D K1330A (AAG>gcG) clones Synthego Custom Experimental models: Organisms/strains Female NSG mice Antitumor assessment core (MSKCC) N/A Oligonucleotides h-GREB1 F: GACAGGACTGTGGACTGGTG R: ATTTGTTTCCAGCCCTCCTT IDT N/A h-TFF1 F: TTGTGGTTTTCCTGGTGTCA R: CCGAGCTCTGGGACTAATCA IDT N/A h-WISP2 F: CAGGGGTCGCAGTCCACAAAA R: AGGCAGTGAGTTAGAGGAAAGG IDT N/A (Continued on next page) Cell Reports 43, 114174, May 28, 2024 17 Article ll OPEN ACCESS

    Recombinant:

    Article Title: Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies V5 tag (D3H8Q) Cell Signaling Technology Cat# 13202; Lot 4 RRID: AB_2687461 KMT2D K1330me1/me2 Eurogentec Custom KMT2D pS1331 Eurogentec Custom Vinculin Cell Signaling Technology Cat# 4650 RRID: AB_10559207 KMT2D Fortis LifeSciences Cat# A300-BL1185, RB X-ALR phospho-AKT (Ser473) (D9E) Cell Signaling Technology Cat# 4060 RRID: AB_2315049 phospho-RXRXX(S/T) (23C8D2) Cell Signaling Technology Cat# 10001 RRID: AB_10950819 HA tag (C29F4) Cell Signaling Technology Cat# 3724 RRID: AB_1549585 SMYD2 (D14H7) Cell Signaling Technology Cat #9734 RRID: AB_10889559 DYKDDDDK Tag (D6W5B) Rabbit mAb Cell Signaling Technology Cat #14793; Lot 7 RRID: AB_2572291 ECLTM Anti-Rabbit IgG Horseradish Peroxidase linked whole antibody (from donkey) GE Healthcare Cat# NA934V; Lot 17010251 RRID: AB_772206 KMT2D ChIP antibody Sigma Aldrich Cat# HPA035877 RRID: AB_10670673 V5 antibody Abcam Cat#ab9116 RRID:AB_307024 H3 Antibody Abcam Cat #ab1791 RRID: AB_302613 Bacterial and virus strains NEB 5-alpha Competent E. coli (High Efficiency) NEB Cat# C2987H Chemicals, peptides, and recombinant proteins 3H-SAM Perkin Elmer NET155V250UC Ultima Gold Scintillation Cocktail Revvity Cat# 6013321 a-Cyano-4-hydroxycinnamic acid Sigma Aldrich Cat#C8982 KMT2D peptides (unmodified, K1330me1, K1330me2, pS1331) Sequence: AHGGRGRGRARL KSTASSIETLVVAD GenScript Custom V5-agarose beads Millipore Sigma Cat# A7345 EZviewTM RED Anti-HA agarose beads Millipore Sigma Cat# E6779 H3 peptide (aa1-21) Genscript Custom MK2206 Selleckchem Catalog No.S1078 Alpelisib Medchem Express Cat# HY-15244 Capivasertib AstraZeneca N/A Fulvestrant Selleckchem Cat# S1191 LLY-507 Sigma Aldrich Cat# SML1279 AZ506 Medchem Express Cat# HY-134828 EPZ033294 Viva Biotech N/A AZ Compound 39 Astra Zeneca N/A (Continued on next page) 16 Cell Reports 43, 114174, May 28, 2024 .. REAGENT or RESOURCE SOURCE IDENTIFIER Doxycycline hydrochloride Millipore Sigma Cat #D3447 Dimethyl Sulfoxide Corning Cat# 25-950-CQC; Lot 01019003 Crystal Violet Sigma Aldrich Cat #V5265 PrestoBlue ThermoFisher Scientific Cat #A13262 Y-27632 Tocris Cat# 1254 TrypLE ThermoFisher Scientific Cat# 12605036 Protein G Dynabeads ThermoFisher Scientific Cat #10004D AMPure beads XP Beckman Coulter A63880 SYBRTM Select Master Mix for CFX Applied Biosystems Cat# 4472942; Lot 00815825 Matrigel Corning Cat# 354262 Lipofectamine 3000 ThermoFisher Scientific Cat# L3000015 Recombinant AKT1 SignalChem Cat#A16-10G Recombinant AKT2 SignalChem Cat #A17-10H Recombinant AKT3 SignalChem Cat #A18-10G Recombinant SGK1 SignalChem Cat #S06-10G Critical commercial assays QuikChange Lightning Site-Directed Mutagenesis Kit Agilent Cat#210518 Q5 mutagenesis kit NEB Cat #E0552S Roche MTT kit Millipore Sigma Cat# 11465007001 Cell-Titer Glo 3D Promega Cat# G9681 Qiagen RNeasy Mini Kit (250) Qiagen Cat# 74106; Lot 163029673 iScriptTM cDNA Synthesis Kit Bio-Rad Cat# 1708891 CUTANA CUT & RUN Kit EpiCypher Cat# 14-1048 CUTANA CUT & RUN Library Prep Kit EpiCypher Cat# 14-1001 Deposited data ChIP-seq/RNA-seq/Cut&Run fastq files This paper GSE255295, GSE253957, GSE253958 Experimental models: Cell lines h-MCF7 ATCC ATCC HTB-22TM h-T47D ATCC ATCC HTB-133TM h-293T ATCC ATCC CRL-3216TM HCI-011 Welm Laboratory N/A HCI-017 Welm Laboratory N/A HCI-018 Welm Laboratory N/A Homozygous KMT2D K1330A (AAG>gcG) clones Synthego Custom Experimental models: Organisms/strains Female NSG mice Antitumor assessment core (MSKCC) N/A Oligonucleotides h-GREB1 F: GACAGGACTGTGGACTGGTG R: ATTTGTTTCCAGCCCTCCTT IDT N/A h-TFF1 F: TTGTGGTTTTCCTGGTGTCA R: CCGAGCTCTGGGACTAATCA IDT N/A h-WISP2 F: CAGGGGTCGCAGTCCACAAAA R: AGGCAGTGAGTTAGAGGAAAGG IDT N/A (Continued on next page) Cell Reports 43, 114174, May 28, 2024 17 Article ll OPEN ACCESS

    Sequencing:

    Article Title: Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
    Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies V5 tag (D3H8Q) Cell Signaling Technology Cat# 13202; Lot 4 RRID: AB_2687461 KMT2D K1330me1/me2 Eurogentec Custom KMT2D pS1331 Eurogentec Custom Vinculin Cell Signaling Technology Cat# 4650 RRID: AB_10559207 KMT2D Fortis LifeSciences Cat# A300-BL1185, RB X-ALR phospho-AKT (Ser473) (D9E) Cell Signaling Technology Cat# 4060 RRID: AB_2315049 phospho-RXRXX(S/T) (23C8D2) Cell Signaling Technology Cat# 10001 RRID: AB_10950819 HA tag (C29F4) Cell Signaling Technology Cat# 3724 RRID: AB_1549585 SMYD2 (D14H7) Cell Signaling Technology Cat #9734 RRID: AB_10889559 DYKDDDDK Tag (D6W5B) Rabbit mAb Cell Signaling Technology Cat #14793; Lot 7 RRID: AB_2572291 ECLTM Anti-Rabbit IgG Horseradish Peroxidase linked whole antibody (from donkey) GE Healthcare Cat# NA934V; Lot 17010251 RRID: AB_772206 KMT2D ChIP antibody Sigma Aldrich Cat# HPA035877 RRID: AB_10670673 V5 antibody Abcam Cat#ab9116 RRID:AB_307024 H3 Antibody Abcam Cat #ab1791 RRID: AB_302613 Bacterial and virus strains NEB 5-alpha Competent E. coli (High Efficiency) NEB Cat# C2987H Chemicals, peptides, and recombinant proteins 3H-SAM Perkin Elmer NET155V250UC Ultima Gold Scintillation Cocktail Revvity Cat# 6013321 a-Cyano-4-hydroxycinnamic acid Sigma Aldrich Cat#C8982 KMT2D peptides (unmodified, K1330me1, K1330me2, pS1331) Sequence: AHGGRGRGRARL KSTASSIETLVVAD GenScript Custom V5-agarose beads Millipore Sigma Cat# A7345 EZviewTM RED Anti-HA agarose beads Millipore Sigma Cat# E6779 H3 peptide (aa1-21) Genscript Custom MK2206 Selleckchem Catalog No.S1078 Alpelisib Medchem Express Cat# HY-15244 Capivasertib AstraZeneca N/A Fulvestrant Selleckchem Cat# S1191 LLY-507 Sigma Aldrich Cat# SML1279 AZ506 Medchem Express Cat# HY-134828 EPZ033294 Viva Biotech N/A AZ Compound 39 Astra Zeneca N/A (Continued on next page) 16 Cell Reports 43, 114174, May 28, 2024 .. REAGENT or RESOURCE SOURCE IDENTIFIER Doxycycline hydrochloride Millipore Sigma Cat #D3447 Dimethyl Sulfoxide Corning Cat# 25-950-CQC; Lot 01019003 Crystal Violet Sigma Aldrich Cat #V5265 PrestoBlue ThermoFisher Scientific Cat #A13262 Y-27632 Tocris Cat# 1254 TrypLE ThermoFisher Scientific Cat# 12605036 Protein G Dynabeads ThermoFisher Scientific Cat #10004D AMPure beads XP Beckman Coulter A63880 SYBRTM Select Master Mix for CFX Applied Biosystems Cat# 4472942; Lot 00815825 Matrigel Corning Cat# 354262 Lipofectamine 3000 ThermoFisher Scientific Cat# L3000015 Recombinant AKT1 SignalChem Cat#A16-10G Recombinant AKT2 SignalChem Cat #A17-10H Recombinant AKT3 SignalChem Cat #A18-10G Recombinant SGK1 SignalChem Cat #S06-10G Critical commercial assays QuikChange Lightning Site-Directed Mutagenesis Kit Agilent Cat#210518 Q5 mutagenesis kit NEB Cat #E0552S Roche MTT kit Millipore Sigma Cat# 11465007001 Cell-Titer Glo 3D Promega Cat# G9681 Qiagen RNeasy Mini Kit (250) Qiagen Cat# 74106; Lot 163029673 iScriptTM cDNA Synthesis Kit Bio-Rad Cat# 1708891 CUTANA CUT & RUN Kit EpiCypher Cat# 14-1048 CUTANA CUT & RUN Library Prep Kit EpiCypher Cat# 14-1001 Deposited data ChIP-seq/RNA-seq/Cut&Run fastq files This paper GSE255295, GSE253957, GSE253958 Experimental models: Cell lines h-MCF7 ATCC ATCC HTB-22TM h-T47D ATCC ATCC HTB-133TM h-293T ATCC ATCC CRL-3216TM HCI-011 Welm Laboratory N/A HCI-017 Welm Laboratory N/A HCI-018 Welm Laboratory N/A Homozygous KMT2D K1330A (AAG>gcG) clones Synthego Custom Experimental models: Organisms/strains Female NSG mice Antitumor assessment core (MSKCC) N/A Oligonucleotides h-GREB1 F: GACAGGACTGTGGACTGGTG R: ATTTGTTTCCAGCCCTCCTT IDT N/A h-TFF1 F: TTGTGGTTTTCCTGGTGTCA R: CCGAGCTCTGGGACTAATCA IDT N/A h-WISP2 F: CAGGGGTCGCAGTCCACAAAA R: AGGCAGTGAGTTAGAGGAAAGG IDT N/A (Continued on next page) Cell Reports 43, 114174, May 28, 2024 17 Article ll OPEN ACCESS

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